Pilocarpine

Evidence Level: N/A

Predicted Indications: 0

Pilocarpine

Pharmacist Assessment Report

Pilocarpine: Known uses and market status in India

Summary

The TxGNN deep-learning model (score ≥ 0.99) produced candidates for Pilocarpine, but every candidate that can be traced to a source is already a known use. There is therefore currently no new predicted indication for this drug. The one known use found among the candidates is primary hereditary glaucoma, which is supported by a licence in another country.

Quick overview

Item	Content
New predicted indications	None (all traceable model candidates are known uses)
Known uses among model candidates	1
Evidence level	Not applicable
India Market Status	Listed in a compiled Indian medicine price dataset (16 of 16) – CDSCO approval status is not included in this data
Number of Listed Products	16 (valid: 16)

Known uses among the model’s candidates

Approved (supported by a licence or label)

Indication	Source
primary hereditary glaucoma	licence in another country (approved indication: glaucoma)

Indication	Approved category
none	none

Relations recorded in the knowledge graph (no approval found)

Indication
none

India Market Information

Licence	Product	Dosage form	Status
36699	Carpinol Eye Drop	bottle of 1 ml Eye Drop	Valid
175055	Pilotbg Tablet	strip of 10 tablets	Valid
36641	Carpine 0.5% Injection	vial of 1 ml Injection	Valid
178124	Pilocar 4% Eye Drop	packet of 5 ml Eye Drop	Valid
173852	Pilomax Tablet	strip of 10 tablets	Valid
176170	Pilomin 0.5% Injection	vial of 1 ml Injection	Valid
177171	Pilocar 1% Eye Drop	packet of 5 ml Eye Drop	Valid
36908	Carpinol Eye Drop	packet of 5 ml Eye Drop	Valid
173863	Pilocar 2% Eye Drop	bottle of 5 ml Eye Drop	Valid
181504	Pilodrops 2% Eye Drop	packet of 5 ml Eye Drop	Valid
43916	Carpine Eye Drop	packet of 5 ml Eye Drop	Valid
129424	Locarp 2% Eye Drop	packet of 5 ml Eye Drop	Valid
177700	Pilocarpin 2% Eye Drop	packet of 5 ml Eye Drop	Valid
176869	Pilo 2 Eye Drop	packet of 5 ml Eye Drop	Valid
182191	Pilagan Eye Drop	packet of 5 ml Eye Drop	Valid
179388	Pilopress Eye Drop	packet of 5 ml Eye Drop	Valid

Safety Considerations

Contraindications suggested by the knowledge graph (not taken from label text; to be verified against the package insert):
- Eye conditions: angle-closure (closed-angle) glaucoma, keratitis, keratoconjunctivitis, iritis, iridocyclitis, uveitis, retinal detachment.
- Respiratory conditions: asthma, chronic obstructive pulmonary disease (including severe early-onset forms), bronchial disease.
- Biliary and liver conditions: cholelithiasis, cholecystolithiasis, choledocholithiasis, cholecystitis, biliary tract disease, obstructive jaundice, liver failure.
- Kidney conditions: nephrolithiasis (including the SLC26A1-related susceptibility form), acute urate nephropathy.
Drug Interactions: 102 interactions were found in total. The moderate-level ones are mainly with other anticholinergic (antimuscarinic) drugs, whose effects may oppose pilocarpine’s:
- Atropine (including ophthalmic)
- Hyoscyamine
- Scopolamine (including ophthalmic)
- Glycopyrronium (including topical)
- Clidinium
- Dicyclomine
- Mepenzolate
- Methscopolamine
- Propantheline
- Trospium
Interactions with pantoprazole, omeprazole, lansoprazole, clotrimazole, morphine, metformin and epinephrine are listed with an unknown severity level.

Package insert warnings and contraindications were not available for this report. Please refer to the package insert for full safety information.

Disclaimer

This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.