Lansoprazole
| Evidence Level: L5 | Predicted Indications: 1 |
Table of Contents
Lansoprazole: Duodenal obstruction
One-Sentence Summary
Lansoprazole is a proton pump inhibitor originally used to treat gastric and duodenal ulcers, gastroesophageal reflux disease, esophagitis, and Zollinger-Ellison syndrome.
Quick Overview
| Item | Content |
|---|---|
| Original Indication | Not recorded in the local data |
| Predicted New Indication | Duodenal obstruction |
| TxGNN Prediction Score | 0.9968 |
| Evidence Level | L5 |
| India Market Status | Listed in a compiled Indian medicine price dataset (at least 20) – CDSCO approval status is not included in this data |
| Number of Listed Products | at least 20 |
| Recommended Decision | Hold |
Why is This Prediction Reasonable?
Detailed mechanism of action data is not available in the data compiled for this report. Based on general knowledge, lansoprazole is a proton pump inhibitor that suppresses gastric acid secretion, and its efficacy in acid-related upper gastrointestinal disease is well established.
Duodenogastric (bile) reflux is the backflow of duodenal contents, including bile and pancreatic fluid, into the stomach. Acid suppression may reduce mucosal injury and symptoms when acid and bile act together. However, lansoprazole does not stop the reflux itself and does not neutralize bile acids, so the mechanistic link is indirect and symptomatic at best.
The high TxGNN score likely reflects the close pathophysiological and network proximity of this condition to lansoprazole’s existing indications (GERD, esophagitis, peptic ulcer), not independent clinical evidence.
A second prediction, duodenal obstruction (score 0.9968), was also generated. It has no identified mechanistic rationale, no trials, and no literature. Obstruction is mainly a mechanical or structural problem, and lansoprazole would at most be an adjunct for associated peptic disease. This prediction is not pursued further here.
Clinical Trial Evidence
Currently no related clinical trials registered.
Literature Evidence
| PMID | Year | Type | Journal | Key Findings |
|---|---|---|---|---|
| 18679668 | 2008 | Review | European Journal of Clinical Pharmacology | General update on PPI clinical use and pharmacokinetics (peptic ulcer, H. pylori, GERD, NSAID-related lesions, Zollinger-Ellison syndrome). Not specific to duodenogastric reflux. |
India Market Information
Twenty valid single-ingredient licences are registered and none are cancelled. The approved indication text is not available for any of them. Five main licences are listed below.
| Authorization Number | Product Name | Dosage Form | Approved Indication |
|---|---|---|---|
| 124137 | Lanzomed 15mg Tablet DT | Dispersible tablet (strip of 10) | Not available |
| 130682 | Lansoford 30mg Tablet | Tablet (strip of 10) | Not available |
| 130379 | Lancron 30mg Capsule | Capsule (strip of 10) | Not available |
| 130532 | Lansotaj 30mg Injection | Powder for injection (1 vial) | Not available |
| 113876 | Junior Lanzol 30mg Tablet DT | Dispersible tablet (strip of 10) | Not available |
Available forms include oral tablets, dispersible tablets, capsules and an injectable powder.
Safety Considerations
- Contraindications suggested by the knowledge graph (not label text): These are graph-derived associations and not confirmed label contraindications. They include long QT syndrome, torsades de pointes, liver failure and liver disease, kidney disease, porphyria, congestive heart failure, myocardial infarction, stroke and cerebrovascular disorders, osteoporosis, blood coagulation disease, anaemia, Clostridium difficile colitis, and myasthenia gravis.
- Drug Interactions: 618 interactions were recorded. Examples:
- Major: acalabrutinib, atazanavir.
- Moderate: hydrochlorothiazide, amphotericin B, amikacin, amphetamine, fenofibrate, apalutamide, aprepitant, atorvastatin, bosutinib, brigatinib, bromocriptine.
- Minor: acetylsalicylic acid, axitinib, brivaracetam, cyanocobalamin.
Please refer to the package insert for official warnings and contraindications.
Conclusion and Next Steps
Decision: Hold
Rationale: The prediction rests only on model score and proximity to existing indications. There are no trials, the single review is not condition-specific, and the mechanism is indirect and symptomatic. Package insert safety data is also missing.
To proceed, the following is needed:
- Condition-specific clinical studies of PPIs (including lansoprazole) in duodenogastric or bile reflux
- Mechanism of action data from DrugBank
- Package insert warnings and contraindications for the Indian products, to allow safety screening
- Approved indication text for the Indian licences
- Review of the knowledge-graph contraindication signals against label information
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.