Artemether
| Evidence Level: L5 | Predicted Indications: 8 |
Table of Contents
Artemether: antimalarial artemisinin derivative → acquired angioedema
One-Sentence Summary
Artemether is an artemisinin-class drug marketed in India in many single-ingredient products. The TxGNN model predicts it may be relevant to acquired angioedema, with a score of 0.9990. However, no clinical trials and no publications were found for this prediction, so it rests on model output alone.
Quick Overview
| Item | Content |
|---|---|
| Original Indication | Not recorded in the local data |
| Predicted New Indication | acquired angioedema |
| TxGNN Prediction Score | 0.9990 |
| Evidence Level | L5 |
| India Market Status | Listed in a compiled Indian medicine price dataset (at least 20) – CDSCO approval status is not included in this data |
| Number of Listed Products | at least 20 |
| Recommended Decision | Hold |
Why is This Prediction Reasonable?
Currently, detailed mechanism of action data is not available for artemether in the data compiled for this report. Artemether belongs to the artemisinin class, and its activity in this class is not known to involve the pathways that drive angioedema.
Acquired angioedema is typically linked to C1-inhibitor deficiency or excess bradykinin signalling (the kallikrein-kinin and complement C1-inhibitor pathways). No mechanistic link between artemether and these pathways has been established. The high score of 0.9990 is a model-based prediction only, and it should not be read as evidence of efficacy.
Other angioedema-related predictions (angioedema, hereditary angioedema, and RAAS-blocker-induced angioedema) appear to share the same model signal, which suggests they reflect similar model patterns rather than independent biological support.
Clinical Trial Evidence
Currently no related clinical trials registered.
Literature Evidence
Currently no related literature available.
India Market Information
At least 20 valid single-ingredient licences are recorded, and the list may be partial. None of the records carry approved-indication text. Examples:
| Authorization Number | Product Name | Dosage Form | Approved Indication |
|---|---|---|---|
| 188232 | Rezatrin 80 mg/480 mg Tablet | Strip of 6 tablets | Not recorded |
| 231992 | Ufither L 80mg/480mg Tablet | Strip of 6 tablets | Not recorded |
| 157460 | Numal Forte Oral Suspension | Bottle of 30 ml oral suspension | Not recorded |
| 190805 | Rezart M 80mg Injection | Vial of 1 ml injection | Not recorded |
| 41355 | Coartrin 20 mg/120 mg Tablet | Strip of 8 tablets | Not recorded |
Safety Considerations
- Drug Interactions: 95 interactions are recorded. Major-level examples include clarithromycin, cobicistat, amprenavir, apalutamide, atazanavir and boceprevir. Moderate-level examples include dexamethasone, miconazole, deferasirox and bosentan.
- Contraindication-related conditions flagged in the data: long QT syndrome, familial long QT syndrome, torsades de pointes and potassium deficiency disease. These come from database relations, not from label text.
Please refer to the package insert for further safety information, as label warnings and contraindications are not available in the data compiled for this report.
Conclusion and Next Steps
Decision: Hold
Rationale: The prediction is supported only by a model score. No trials or publications address acquired angioedema, no mechanistic link is known, and the evidence level is L5.
To proceed, the following is needed:
- Mechanism of action data for artemether
- Preclinical evidence that artemether acts on bradykinin, kallikrein or complement pathways
- Package insert warnings and contraindications, with particular attention to QT-related risk
- Any clinical or literature evidence directly studying artemether in acquired angioedema
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.